LITTLE KNOWN FACTS ABOUT RAS-IN-2.

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Watch Carefully (one)crofelemer improves levels of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the opportunity to inhibit CYP3A4 at concentrations expected during the gut; unlikely to inhibit systemically due to the fact minimally absorbed.Steer clear of or Use Alternate Drug. Steer clear